By Robert Preidt
FRIDAY, Oct. 9, 2020 (HealthDay Information) — The so-called love hormone, oxytocin, could also be price investigating as a therapy for COVID-19, a brand new examine suggests.
Some of the severe problems of an infection with the new coronavirus is a “cytokine storm,” during which the physique assaults its personal tissues.
There are presently no U.S. Meals and Drug Administration-approved therapies for COVID-19, which implies that “repurposing present medication that may act on the adaptive immune response and stop the cytokine storm in early phases of the illness is a precedence,” in accordance with the researchers.
On this new examine, researcher Ali Imami, a graduate analysis assistant on the College of Toledo in Ohio, and colleagues used a U.S. Nationwide Institutes of Well being database to research traits of genes handled with medication intently associated to oxytocin.
The investigators discovered that one drug particularly, carbetocin, has comparable traits (known as a signature) to genes with lowered expression of the inflammatory markers that set off cytokine storm in COVID-19 sufferers.
Carbetocin’s signature means that the drug could set off activation of immune cells known as T-cells that play an necessary function in immune response. As well as, carbetocin’s signature can be much like that of lopinavir, an antiretroviral medicine underneath examine as a therapy for COVID-19.
All of those components point out that oxytocin could have potential as a focused therapy for cytokine storms in COVID-19 sufferers, the researchers stated in a information launch from the American Physiological Society.
“Understanding the mechanisms by which oxytocin or the oxytocin system could be a new immune goal is essential,” the authors concluded of their report, which was printed on-line not too long ago within the journal Physiological Genomics.
Nonetheless, they added that “security and efficacy of intravenous oxytocin in hospitalized sufferers with COVID-19 stays to be assessed.”